
I got here the slow way.
Certified Functional Medicine Health Consultant, Nutritionist, and CrossFit Level-2 Trainer
For a stretch I walked with a cane, holding a diagnosis whose standard answer was lifelong management. I went looking for the mechanism instead, and eventually published what I found.
My doctorate is in Mechanical & Aerospace Engineering at Cornell. The research applied thermodynamics to both mechanical systems and human biology: how energy moves through a system, what it has to dissipate, and what happens when that accounting stops balancing.

Before any of that, I played Division I golf. Then I was diagnosed with Ankylosing Spondylitis, with radiographic bilateral sacroiliitis. For a stretch I walked with a cane. The path on offer was TNF-α inhibitors and IL-17 blockers, meaning management indefinitely, and nobody was especially interested in the question I couldn’t stop asking, which was why.
So I went at it the way I’d been trained to. I worked alongside osteopathic and functional medicine clinicians, took coursework in functional immunology, and stopped looking for a single culprit. Instead I broke the body into three interacting systems (neuro-endocrine function, the intestinal-immune axis, and detox pathways) and worked on them in an order that let me actually attribute the result.
The things that moved my case were reducing pathogen burden, so mitigating mold exposure, addressing gut dysbiosis, and restoring mitochondrial function. A year later I had reached clinical remission, documented with post-treatment MRI. I wrote it up as a case report and submitted it to The Journal of Immunology.
I want to be precise about what that is: one case, mine, not a controlled trial. It doesn’t establish that the same approach works for anyone else, which is exactly why I teach the method instead of selling an outcome.
My mission is to ignite curiosity in people who are suffering and give them enough of the underlying science to take charge of their own health, including being harder to sell to. Me included.
Published research
The case report
Clinical remission of spondyloarthritis achieved through reducing pathogen burden and restoring redox homeostasis: A case report and literature review
Nicholas DiReda, Ph.D.
Department of Mechanical and Aerospace Engineering, Cornell University
Preprint submitted to The Journal of Immunology · April 25, 2024
The case report documents my own diagnosis, Ankylosing Spondylitis with radiographic bilateral sacroiliitis, and the approach that followed: mitigating mold exposure, addressing gut dysbiosis, and restoring mitochondrial function, rather than escalating TNF-α inhibitors or IL-17 blockers.
One year on, the case reached clinical remission, documented with post-treatment MRI and symptomatic follow-up.
From my medical record
“HLA B27 positive Sacroiliitis: This has nearly completely resolved radiologically, without any associated symptoms, and without pharmacologic intervention.”
It is a single case report, mine, and not a controlled trial, and it does not establish that the same approach will work for anyone else. It is why I teach the method rather than sell an outcome.
Background
Credentials, stated plainly
I think you should know exactly what I am and what I’m not before you take anything here seriously.
- Ph.D., Mechanical & Aerospace Engineering, Cornell University
- Doctoral research applying thermodynamics to human biology
- Certified Functional Medicine Health Consultant
- Nutritionist / Certified Nutrition Coach
- CrossFit Level-2 Trainer
- Former D1 golfer · regenerative rancher
What I am not
Not a physician. Not a licensed dietitian. I don’t diagnose conditions, order or interpret treatment, or manage medication. If you need any of those, you need a doctor, and this material is built to make those appointments more useful, not to substitute for them.
Where should you start?
Five questions and I’ll tell you, including telling you to buy nothing, if that’s the right answer.
Find your starting pointNicholas DiReda holds a Ph.D. in engineering and is not a medical doctor. This site is educational and is not medical advice, diagnosis, or treatment. Nothing here replaces care from a licensed physician. Always consult your doctor before changing your diet, supplements, or medication.